TGFβ

[Scientific Reports] Researchers found that cells lacking the desmosomal cadherin Desmoglein-2 displayed a significant increase in spreading area on both fibronectin and collagen, compared to control A431 cells.

[Nature] Scientists evaluated outcomes in 581 patients who had undergone surgery and were evaluable for ctDNA from a randomized phase III trial of adjuvant atezolizumab versus observation in operable urothelial cancer.

[Nature Communications] The proximal colonic tumors that developed in a mouse model of right-sided colon cancer exhibited a fetal-like progenitor phenotype (Ly6a/Sca1+) and lacked expression of Lgr5 and its associated intestinal stem cell signature.

[Scientific Reports] Scientists studied the biological function of cytoplasmic maspin in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus.

[Scientific Reports] Researchers created neural progenitor cells (NPC) derived from individuals with chromosome 2q23.1 deletion and conducted RNA-seq to identify differentially expressed genes (DEGs) and the biological processes and pathways altered in MAND.

[Scholar Rock (Business Wire, Inc.)] Scholar Rock, a clinical-stage biopharmaceutical company, announced that the US FDA has granted Fast Track designation for apitegromab, a selective inhibitor of myostatin activation, for the treatment of patients with Spinal Muscular Atrophy.