Oncogenic BRAF, Unrestrained by TGFβ-Receptor Signaling, Drives Right-Sided Colonic Tumorigenesis

The proximal colonic tumors that developed in a mouse model of right-sided colon cancer exhibited a fetal-like progenitor phenotype (Ly6a/Sca1+) and lacked expression of Lgr5 and its associated intestinal stem cell signature.