tuberculosis

[infection and Drug Resistance] Scientists estimated the role of miR-340-5p in Mycobacterium tuberculosis-infected alveolar type II cells.

[Journal of Clinical Investigation] Mycobacterium tuberculosis-specific CD4 T cells producing TNF-α, IL-2 and IL-17 were highly expanded in the lung compared to matched blood samples, in which IL-17+ cells were largely absent.

[Cell Chemical Biology] Tryptophan biosynthesis represents an important potential drug target for new anti-TB drugs. Scientists identified a series of indole-4-carboxamides with potent antitubercular activity.

[Cell] Researchers found that type 2 immune signaling, mediated via stat6, was absolutely required for epithelialization and granuloma formation.

[Cell Host & Microbe] In a murine infection model, scientists observed that IFNɣ production by Mtb-specific CD4 T cells was rapidly extinguished within the granuloma but not within unaffected lung regions, suggesting localized immunosuppression.

[Clinical Infectious Diseases] Scientists queried the diagnostic ability of phenotypic markers on Mycobacterium tuberculosis-specific cytokine-producing immune cell subsets for identifying active tuberculosis.