TGFβ Restricts Expansion, Survival, and Function of T Cells within the Tuberculous Granuloma

By
Justin.choi
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0
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In a murine infection model, scientists observed that IFNɣ production by Mtb-specific CD4 T cells was rapidly extinguished within the granuloma but not within unaffected lung regions, suggesting localized immunosuppression.
[Cell Host & Microbe]
Gern, B. H., Adams, K. N., Plumlee, C. R., Stoltzfus, C. R., Shehata, L., Moguche, A. O., Busman-Sahay, K., Hansen, S. G., Axthelm, M. K., Picker, L. J., Estes, J. D., Urdahl, K. B., & Gerner, M. Y. (2021). TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma. Cell Host & Microbe, 0(0). https://doi.org/10.1016/j.chom.2021.02.005 Cite
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