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Pulmonary Cell NewsMycobacterium tuberculosis-specific CD4 T cells producing TNF-α, IL-2 and IL-17 were highly expanded in the lung compared to matched blood samples, in which IL-17+ cells were largely absent.
[Journal of Clinical Investigation]
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Ogongo, P., Tezera, L. B., Ardain, A., Nhamoyebonde, S., Ramsuran, D., Singh, A., Ngoepe, A., Karim, F., Naidoo, T., Khan, K., Dullabh, K. J., Fehlings, M., Lee, B. H., Nardin, A., Arlehamn, C. S. L., Sette, A., Behar, S. M., Steyn, A. J. C., Madansein, R., … Leslie, A. (2021). Tissue resident-like CD4+ T cells secreting IL-17 control Mycobacteria tuberculosis in the human lung. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI142014 Cite
