Publication

[Journal Of Experimental Medicine] Scientists reported massive acute myeloid leukemia (AML) cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model. These AML cells could regenerate AML after transplantation. Prospective niche characterization revealed that skin harbored mesenchymal progenitor cells with a similar phenotype as BM mesenchymal stem cells.

[Frontiers In Immunology] The authors employed the combinatorial assay matrix approach, including a panel of well standardized assays, such as flow cytometry, multiplex secretome analysis, and metabolic assays, to define the phenotype and functionality of human-donor-derived primary MSCs exposed to the representative xenobiotic Atrazine.

[Cell Reports] Investigators describe the systematic derivation, propagation, and characterization of multiple distinct glioblastoma stem cells from single, treatment-naive glioblastoma.

[Brain] The authors described 17 individuals with an autosomal dominant muscular dystrophy belonging to two unrelated families in which different heterozygous truncating variants in the last exon of MAMDC2 co-segregate correctly with the disease.

[Nature Communications] In vitro and in vivo assays demonstrated that Schwann cells enhanced the proliferation and migration of PDAC cells via Midkine signaling, and promoted the switch of cancer-associated fibroblasts (CAFs) to basal-like and inflammatory CAFs via interleukin-1α.

[Digestive Endoscopy] Various clinicopathologic factors, including the tumor size, tumor location, clinical stage, histologic subtype, and tumor differentiation, did not influence the patient-derived organoid establishment.