Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-Tumor Activity

The authors developed human cytokine-inducible SH2-containing protein-knockout (CISH^−/−) NK cells using an induced pluripotent stem cell-derived NK cell (iPSC-NK cell) platform. CISH^−/− iPSC-NK cells demonstrated increased IL-15-mediated JAK-STAT signaling activity.