Impaired AKT Signaling and Lung Tumorigenesis by PIERCE1 Ablation in KRAS-Mutant Non-Small Cell Lung Cancer

By
Justin.choi
-
0
5
Investigators showed the tumor-promoting function of a cell cycle-related protein, PIERCE1, in KRAS-mutant non-small cell lung cancer. Mechanistically, PIERCE1 depletion inhibited cell growth and AKT phosphorylation at S473, which was particularly observed in KRAS-mutant lung cancers.
[Oncogene]
Roh, J., Lee, J., Sung, Y.-H., Oh, J., Hyeon, D. Y., Kim, Y., Lee, S., Devkota, S., Kim, H. J., Park, B., Nam, T., Song, Y., Kim, Y., Hwang, D., & Lee, H.-W. (2020). Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer. Oncogene, 1–12. https://doi.org/10.1038/s41388-020-01399-5 Cite
Full Article