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Pulmonary Cell NewsThe authors define transcriptional consequences of reduced dosage of the CHD transcription factor, TBX5, in individual cells during cardiomyocyte differentiation from human iPSCs.
[Developmental Cell]
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Kathiriya, I. S., Rao, K. S., Iacono, G., Devine, W. P., Blair, A. P., Hota, S. K., Lai, M. H., Garay, B. I., Thomas, R., Gong, H. Z., Wasson, L. K., Goyal, P., Sukonnik, T., Hu, K. M., Akgun, G. A., Bernard, L. D., Akerberg, B. N., Gu, F., Li, K., … Bruneau, B. G. (2020). Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.11.020 Cite
