Scientists used two-photon microscopy and followed neural stem cells that were genetically labeled through conditional recombination driven by the regulatory elements of the stem cell-expressed genes GLI family zinc finger 1 or achaete-scute homolog 1.
[Nature Neuroscience]
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Bottes, S., Jaeger, B. N., Pilz, G.-A., Jörg, D. J., Cole, J. D., Kruse, M., Harris, L., Korobeynyk, V. I., Mallona, I., Helmchen, F., Guillemot, F., Simons, B. D., & Jessberger, S. (2020). Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging. Nature Neuroscience, 1–9. https://doi.org/10.1038/s41593-020-00759-4 Cite