Investigators discuss that the Pyk2-mediated actin polymerization pathway in osteoclasts and microglia in bone and brain, respectively, is the horizontal pleiotropic mediator of shared risk factors for osteoporosis and Alzheimer’s disease.
[Bone Research]
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Lee, J.-W., Lee, I.-H., Iimura, T., & Kong, S. W. (2021). Two macrophages, osteoclasts and microglia: from development to pleiotropy. Bone Research, 9(1), 1–10. https://doi.org/10.1038/s41413-020-00134-w Cite