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Pulmonary Cell NewsUsing primary epithelial organoids from human colon, researchers explored how the central antiviral mediator IFN‐γ, which is elevated in COVID‐19, affected epithelial cell differentiation, ACE2 expression, and susceptibility to infection with SARS‐CoV‐2.
[EMBO Molecular Medicine]
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Heuberger, J., Trimpert, J., Vladimirova, D., Goosmann, C., Lin, M., Schmuck, R., Mollenkopf, H.-J., Brinkmann, V., Tacke, F., Osterrieder, N., & Sigal, M. (2021). Epithelial response to IFN-γ promotes SARS-CoV-2 infection. EMBO Molecular Medicine, n/a(n/a), e13191. https://doi.org/10.15252/emmm.202013191 Cite
