Mechanistically, plectin deficiency in intestinal epithelial cell led to aberrant keratin filament network organization and the formation of dysfunctional hemidesmosomes and intercellular junctions.
[Mucosal Immunology]
6445212
{6445212:7X6UANEB}
apa
50
1
160042
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-edd00079745f54b91b6f9b4f9f068a27%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%227X6UANEB%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Krausova%20et%20al.%22%2C%22parsedDate%22%3A%222021-03-05%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EKrausova%2C%20A.%2C%20Buresova%2C%20P.%2C%20Sarnova%2C%20L.%2C%20Oyman-Eyrilmez%2C%20G.%2C%20Skarda%2C%20J.%2C%20Wohl%2C%20P.%2C%20Bajer%2C%20L.%2C%20Sticova%2C%20E.%2C%20Bartonova%2C%20L.%2C%20Pacha%2C%20J.%2C%20Koubkova%2C%20G.%2C%20Prochazka%2C%20J.%2C%20Sp%26%23xF6%3Brrer%2C%20M.%2C%20D%26%23xFC%3Brrbeck%2C%20C.%2C%20Stehlikova%2C%20Z.%2C%20Vit%2C%20M.%2C%20Ziolkowska%2C%20N.%2C%20Sedlacek%2C%20R.%2C%20Jirak%2C%20D.%2C%20%26%23x2026%3B%20Gregor%2C%20M.%20%282021%29.%20Plectin%20ensures%20intestinal%20epithelial%20integrity%20and%20protects%20colon%20against%20colitis.%20%3Ci%3EMucosal%20Immunology%3C%5C%2Fi%3E%2C%201%26%23x2013%3B12.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41385-021-00380-z%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41385-021-00380-z%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3D7X6UANEB%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Plectin%20ensures%20intestinal%20epithelial%20integrity%20and%20protects%20colon%20against%20colitis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alzbeta%22%2C%22lastName%22%3A%22Krausova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petra%22%2C%22lastName%22%3A%22Buresova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lenka%22%2C%22lastName%22%3A%22Sarnova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gizem%22%2C%22lastName%22%3A%22Oyman-Eyrilmez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jozef%22%2C%22lastName%22%3A%22Skarda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pavel%22%2C%22lastName%22%3A%22Wohl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Bajer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eva%22%2C%22lastName%22%3A%22Sticova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lenka%22%2C%22lastName%22%3A%22Bartonova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jiri%22%2C%22lastName%22%3A%22Pacha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gizela%22%2C%22lastName%22%3A%22Koubkova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Prochazka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marina%22%2C%22lastName%22%3A%22Sp%5Cu00f6rrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22D%5Cu00fcrrbeck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zuzana%22%2C%22lastName%22%3A%22Stehlikova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Vit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Ziolkowska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Radislav%22%2C%22lastName%22%3A%22Sedlacek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Jirak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miloslav%22%2C%22lastName%22%3A%22Kverka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerhard%22%2C%22lastName%22%3A%22Wiche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%22%2C%22lastName%22%3A%22Fabry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vladimir%22%2C%22lastName%22%3A%22Korinek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Gregor%22%7D%5D%2C%22abstractNote%22%3A%22Plectin%2C%20a%20highly%20versatile%20cytolinker%20protein%2C%20provides%20tissues%20with%20mechanical%20stability%20through%20the%20integration%20of%20intermediate%20filaments%20%28IFs%29%20with%20cell%20junctions.%20Here%2C%20we%20hypothesize%20that%20plectin-controlled%20cytoarchitecture%20is%20a%20critical%20determinant%20of%20the%20intestinal%20barrier%20function%20and%20homeostasis.%20Mice%20lacking%20plectin%20in%20an%20intestinal%20epithelial%20cell%20%28IEC%3B%20Ple%5Cu0394IEC%29%20spontaneously%20developed%20colitis%20characterized%20by%20extensive%20detachment%20of%20IECs%20from%20the%20basement%20membrane%20%28BM%29%2C%20increased%20intestinal%20permeability%2C%20and%20inflammatory%20lesions.%20Moreover%2C%20plectin%20expression%20was%20reduced%20in%20the%20colons%20of%20ulcerative%20colitis%20%28UC%29%20patients%20and%20negatively%20correlated%20with%20the%20severity%20of%20colitis.%20Mechanistically%2C%20plectin%20deficiency%20in%20IECs%20led%20to%20aberrant%20keratin%20filament%20%28KF%29%20network%20organization%20and%20the%20formation%20of%20dysfunctional%20hemidesmosomes%20%28HDs%29%20and%20intercellular%20junctions.%20In%20addition%2C%20the%20hemidesmosomal%20%5Cu03b16%5Cu03b24%20integrin%20%28Itg%29%20receptor%20showed%20attenuated%20association%20with%20KFs%2C%20and%20protein%20profiling%20revealed%20prominent%20downregulation%20of%20junctional%20constituents.%20Consistent%20with%20the%20effects%20of%20plectin%20loss%20in%20the%20intestinal%20epithelium%2C%20plectin-deficient%20IECs%20exhibited%20remarkably%20reduced%20mechanical%20stability%20and%20limited%20adhesion%20capacity%20in%20vitro.%20Feeding%20mice%20with%20a%20low-residue%20liquid%20diet%20that%20reduced%20mechanical%20stress%20and%20antibiotic%20treatment%20successfully%20mitigated%20epithelial%20damage%20in%20the%20Ple%5Cu0394IEC%20colon.%22%2C%22date%22%3A%222021-03-05%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41385-021-00380-z%22%2C%22ISSN%22%3A%221935-3456%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41385-021-00380-z%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-12T17%3A58%3A14Z%22%7D%7D%5D%7D
Krausova, A., Buresova, P., Sarnova, L., Oyman-Eyrilmez, G., Skarda, J., Wohl, P., Bajer, L., Sticova, E., Bartonova, L., Pacha, J., Koubkova, G., Prochazka, J., Spörrer, M., Dürrbeck, C., Stehlikova, Z., Vit, M., Ziolkowska, N., Sedlacek, R., Jirak, D., … Gregor, M. (2021). Plectin ensures intestinal epithelial integrity and protects colon against colitis. Mucosal Immunology, 1–12. https://doi.org/10.1038/s41385-021-00380-z Cite
