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Pulmonary Cell NewsResearchers discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks, large Brd4-bound enhancer usage, and Brd4 localization to Myc and p53 genomic binding sites. These sex-biased gene expression patterns were also evident in human glioblastoma stem cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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Kfoury, N., Qi, Z., Prager, B. C., Wilkinson, M. N., Broestl, L., Berrett, K. C., Moudgil, A., Sankararaman, S., Chen, X., Gertz, J., Rich, J. N., Mitra, R. D., & Rubin, J. B. (2021). Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma. Proceedings of the National Academy of Sciences, 118(16). https://doi.org/10.1073/pnas.2017148118 Cite
