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Pulmonary Cell NewsCSCs had low EGFR expression and, conversely, overexpressed the anti-apoptotic Bcl-2 protein, which is involved in resistance to apoptosis and the invasion/migration capacities of tumor cells.
[Journal of Cancer Research and Clinical Oncology]
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Guy, J.-B., Espenel, S., Louati, S., Gauthier, A., Garcia, M.-A., Vial, N., Malésys, C., Ardail, D., Alphonse, G., Wozny, A.-S., Rodriguez-Lafrasse, C., & Magné, N. (2021). Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-021-03593-8 Cite
