CSCs had low EGFR expression and, conversely, overexpressed the anti-apoptotic Bcl-2 protein, which is involved in resistance to apoptosis and the invasion/migration capacities of tumor cells.
[Journal of Cancer Research and Clinical Oncology]
6445212
{6445212:XXB24EGG}
apa
50
1
161161
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-ef9bf0a5259149dd11d0d8d070618f45%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22XXB24EGG%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guy%20et%20al.%22%2C%22parsedDate%22%3A%222021-03-31%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGuy%2C%20J.-B.%2C%20Espenel%2C%20S.%2C%20Louati%2C%20S.%2C%20Gauthier%2C%20A.%2C%20Garcia%2C%20M.-A.%2C%20Vial%2C%20N.%2C%20Mal%26%23xE9%3Bsys%2C%20C.%2C%20Ardail%2C%20D.%2C%20Alphonse%2C%20G.%2C%20Wozny%2C%20A.-S.%2C%20Rodriguez-Lafrasse%2C%20C.%2C%20%26amp%3B%20Magn%26%23xE9%3B%2C%20N.%20%282021%29.%20Combining%20radiation%20to%20EGFR%20and%20Bcl-2%20blockade%3A%20a%20new%20approach%20to%20target%20cancer%20stem%20cells%20in%20head%20and%20neck%20squamous%20cell%20carcinoma.%20%3Ci%3EJournal%20of%20Cancer%20Research%20and%20Clinical%20Oncology%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00432-021-03593-8%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00432-021-03593-8%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DXXB24EGG%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Combining%20radiation%20to%20EGFR%20and%20Bcl-2%20blockade%3A%20a%20new%20approach%20to%20target%20cancer%20stem%20cells%20in%20head%20and%20neck%20squamous%20cell%20carcinoma%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Baptiste%22%2C%22lastName%22%3A%22Guy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Espenel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Safa%22%2C%22lastName%22%3A%22Louati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Gauthier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max-Adrien%22%2C%22lastName%22%3A%22Garcia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Vial%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9line%22%2C%22lastName%22%3A%22Mal%5Cu00e9sys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Ardail%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gersende%22%2C%22lastName%22%3A%22Alphonse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Sophie%22%2C%22lastName%22%3A%22Wozny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Rodriguez-Lafrasse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Magn%5Cu00e9%22%7D%5D%2C%22abstractNote%22%3A%22The%20clinical%20outcome%20of%20head%20and%20neck%20squamous%20cell%20carcinoma%20%28HNSCC%29%20remains%20poor%2C%20partly%20due%20to%20the%20presence%20of%20resistant%20cancer%20stem%20cells%20%28CSCs%29%20which%20are%20responsible%20of%20recurrences.%20CSCs%20have%20low%20EGFR%20expression%20and%2C%20conversely%2C%20overexpress%20the%20anti-apoptotic%20Bcl-2%20protein%2C%20which%20is%20involved%20in%20resistance%20to%20apoptosis%20and%20the%20invasion%5C%2Fmigration%20capacities%20of%20tumour%20cells.%22%2C%22date%22%3A%222021-03-31%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00432-021-03593-8%22%2C%22ISSN%22%3A%221432-1335%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00432-021-03593-8%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-14T18%3A23%3A45Z%22%7D%7D%5D%7D
Guy, J.-B., Espenel, S., Louati, S., Gauthier, A., Garcia, M.-A., Vial, N., Malésys, C., Ardail, D., Alphonse, G., Wozny, A.-S., Rodriguez-Lafrasse, C., & Magné, N. (2021). Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-021-03593-8 Cite
