ULK1 Inhibition Overcomes Compromised Antigen Presentation and Restores Antitumor Immunity in LKB1-Mutant Lung Cancer

By
Justin.choi
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Investigators found that LKB1 deficiency correlated with elevated tumor mutational burden (TMB) in nonsmall cell lung cancers from nonsmokers and genetically engineered mouse models, despite the frequent association between high-TMB and anti-PD-1 treatment efficacy.
[Nature Cancer]
Deng, J., Thennavan, A., Dolgalev, I., Chen, T., Li, J., Marzio, A., Poirier, J. T., Peng, D. H., Bulatovic, M., Mukhopadhyay, S., Silver, H., Papadopoulos, E., Pyon, V., Thakurdin, C., Han, H., Li, F., Li, S., Ding, H., Hu, H., … Wong, K.-K. (2021). ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 -mutant lung cancer. Nature Cancer, 1–12. https://doi.org/10.1038/s43018-021-00208-6 Cite
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