Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists investigated the role of ascorbic acid, calcitriol, retinoic acid, and alfa-tocopherol as inductors of molecules related to mycobacterial contention in macrophages and epithelial cells.
[Peptides]
6445212 DCTLIIRE items 1 apa 0 default asc 1 162626 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d9bceea412f43ce8073a4ad4095cafe8%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22DCTLIIRE%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jacobo-Delgado%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-24%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EJacobo-Delgado%2C%20Y.%20M.%2C%20Torres-Juarez%2C%20F.%2C%20Alonso-Macias%2C%20J.%2C%20deHaro-Acosta%2C%20J.%2C%20Rodr%26%23xED%3Bguez-Carlos%2C%20A.%2C%20Rivas-Santiago%2C%20C.%2C%20Santos-Mena%2C%20A.%2C%20Enciso-Moreno%2C%20J.%20E.%2C%20Marin-Luevano%2C%20S.%20P.%2C%20%26amp%3B%20Rivas-Santiago%2C%20B.%20%282021%29.%20Retinoic%20acid%20promotes%20Mycobacterium%20tuberculosis%20elimination%20inducing%20antimicrobial%20peptides%20and%20cytokines.%20%3Ci%3EPeptides%3C%5C%2Fi%3E%2C%20170580.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.peptides.2021.170580%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.peptides.2021.170580%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DDCTLIIRE%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Retinoic%20acid%20promotes%20Mycobacterium%20tuberculosis%20elimination%20inducing%20antimicrobial%20peptides%20and%20cytokines%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yolanda%20M.%22%2C%22lastName%22%3A%22Jacobo-Delgado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Flor%22%2C%22lastName%22%3A%22Torres-Juarez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Alonso-Macias%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeny%22%2C%22lastName%22%3A%22deHaro-Acosta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adri%5Cu00e1n%22%2C%22lastName%22%3A%22Rodr%5Cu00edguez-Carlos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cesar%22%2C%22lastName%22%3A%22Rivas-Santiago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alan%22%2C%22lastName%22%3A%22Santos-Mena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9%20E.%22%2C%22lastName%22%3A%22Enciso-Moreno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%20P.%22%2C%22lastName%22%3A%22Marin-Luevano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Rivas-Santiago%22%7D%5D%2C%22abstractNote%22%3A%22Tuberculosis%20%28TB%29%20is%20the%20leading%20cause%20of%20death%20by%20a%20single%20infectious%20agent%2C%20Mycobacterium%20tuberculosis%20%28Mtb%29.%20The%20alveolar%20macrophages%20and%20epithelial%20cells%20are%20the%20first%20cells%20exposed%20to%20Mtb%20during%20the%20primary%20infection%2C%20once%20these%20cells%20are%20activated%2C%20secrete%20soluble%20factors%20such%20as%20cytokines%20and%20antimicrobial%20peptides%20that%20are%20associated%20with%20the%20Mtb%20contention%20and%20elimination.%20The%20vitamins%20are%20micronutrients%20that%20function%20as%20boosters%20on%20the%20innate%20immune%20system%2C%20nevertheless%2C%20is%20unclear%20whether%20they%20have%20any%20protective%20activity%20during%20Mtb%20infection.%20Thus%2C%20we%20investigated%20the%20role%20of%20ascorbic%20acid%2C%20calcitriol%20%28vitamin%20D%29%2C%20retinoic%20acid%2C%20and%20alfa-tocopherol%20as%20inductors%20of%20molecules%20related%20to%20mycobacterial%20contention%20in%20macrophages%20and%20epithelial%20cells.%20We%20observed%20that%20retinoic%20acid%20enhances%20the%20Mtb%20elimination%20in%20epithelial%20cells%2C%20thus%20we%20decided%20to%20explore%20which%20molecules%20were%20involved.%20Our%20results%20showed%20that%20retinoic%20acid%20promotes%20the%20expression%20of%20pro-%20and%20anti-inflammatory%20molecules%20such%20as%20TSLP%2C%20%5Cu03b2-defensin-2%2C%20IL-1%5Cu03b2%2C%20CCL20%2C%20%5Cu03b2-defensin-3%2C%20Cathelicidin%20LL-37%2C%20TGF-%5Cu03b2%2C%20and%20RNase%207%2C%20whereas%20vitamin%20D%2C%20ascorbic%20acid%2C%20and%20%5Cu03b1-tocopherol%20shows%20an%20anti-inflammatory%20response.%20Thereby%20we%20propose%20that%20retinoic%20acid%20supplementation%20drives%20the%20immune%20response%20and%20promotes%20the%20Mtb%20elimination%20by%20increasing%20the%20expression%20of%20distinct%20soluble%20molecules%2C%20whereas%20modulates%20the%20inflammation%20response%20to%20avoid%20damage%20to%20host%20tissues.%22%2C%22date%22%3A%22May%2024%2C%202021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.peptides.2021.170580%22%2C%22ISSN%22%3A%220196-9781%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0196978121000887%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-05-26T16%3A44%3A10Z%22%7D%7D%5D%7D
Jacobo-Delgado, Y. M., Torres-Juarez, F., Alonso-Macias, J., deHaro-Acosta, J., Rodríguez-Carlos, A., Rivas-Santiago, C., Santos-Mena, A., Enciso-Moreno, J. E., Marin-Luevano, S. P., & Rivas-Santiago, B. (2021). Retinoic acid promotes Mycobacterium tuberculosis elimination inducing antimicrobial peptides and cytokines. Peptides, 170580. https://doi.org/10.1016/j.peptides.2021.170580 Cite
