Multimodally Profiling Memory T Cells from a Tuberculosis Cohort Identifies Cell State Associations with Demographics, Environment and Disease

By
Justin.choi
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The authors integrated single-cell RNA and surface protein data from 500,089 memory T cells to define 31 cell states from 259 individuals in a Peruvian tuberculosis progression cohort.
[Nature Immunology]
Nathan, A., Beynor, J. I., Baglaenko, Y., Suliman, S., Ishigaki, K., Asgari, S., Huang, C.-C., Luo, Y., Zhang, Z., Lopez, K., Lindestam Arlehamn, C. S., Ernst, J. D., Jimenez, J., Calderón, R. I., Lecca, L., Van Rhijn, I., Moody, D. B., Murray, M. B., & Raychaudhuri, S. (2021). Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease. Nature Immunology, 1–13. https://doi.org/10.1038/s41590-021-00933-1 Cite
Abstract