The Phosphatase PRL-3 Affects Intestinal Homeostasis by Altering the Crypt Cell Composition

Researchers employed a doxycycline-inducible phosphatase of regenerating liver-3 (PRL-3) mouse strain to show that aberrant PRL-3 expression within a non-cancerous background led to the death of Lgr5+ intestinal stem cells and to Paneth cell expansion.