ac4C Acetylation of RUNX2 Catalyzed by NAT10 Promotes Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells and Prevents Ovariectomy-Induced Bone Loss

Investigators explored the relationships among osteoblast differentiation, N-acetyltransferase 10 (NAT10) , and N4-acetylcytidine (ac4C) and found that NAT0 expression and the ac4C level of total RNA were decreased in the bone tissues of OVX mice and osteoporosis patients.