Inhibition of EZH2 Prevents Acute Respiratory Distress Syndrome (ARDS)-Associated Pulmonary Fibrosis by Regulating the Macrophage Polarization Phenotype

The authors investigated the role and mechanisms of enhancer of zeste homolog 2 (EZH2) in pulmonary fibrosis in a murine model of LPS-induced acute respiratory distress syndrome (ARDS) and in ex vivo cultured alveolar macrophages and mouse lung epithelial cell line by using 3-deazaneplanocin and EZH2 the small interfering RNA.