Mutant p53 Attenuates Oxidative Phosphorylation and Facilitates Cancer Stemness through Downregulating microRNA-200c-PCK2 Axis in Basal-Like Breast Cancer

The authors demonstrated that CRISPR-mediated knockout of miR-200c induced metabolic features similar to the metabolic rewiring caused by p53 hot-spot mutations, and that impairing this metabolic reprogramming interfered with miR-200c deficiency-induced stemness and transformation.