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Pulmonary Cell NewsUsing cells from patients and newly generated mouse models, investigators uncovered ELF4-mutant macrophages having hyperinflammatory responses to a range of innate stimuli.
[Nature Immunology]
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Tyler, P. M., Bucklin, M. L., Zhao, M., Maher, T. J., Rice, A. J., Ji, W., Warner, N., Pan, J., Morotti, R., McCarthy, P., Griffiths, A., van Rossum, A. M. C., Hollink, I. H. I. M., Dalm, V. A. S. H., Catanzaro, J., Lakhani, S. A., Muise, A. M., & Lucas, C. L. (2021). Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation. Nature Immunology, 1–9. https://doi.org/10.1038/s41590-021-00984-4 Cite
