Responsiveness to Perturbations Is a Hallmark of Transcription Factors That Maintain Cell Identity In Vitro

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Investigators developed perturbation panel profiling as a framework for perturbing cells across many conditions and measuring gene expression responsiveness transcriptome-wide.
[Cell Systems]
Mellis, I. A., Edelstein, H. I., Truitt, R., Goyal, Y., Beck, L. E., Symmons, O., Dunagin, M. C., Saldana, R. A. L., Shah, P. P., Pérez-Bermejo, J. A., Padmanabhan, A., Yang, W., Jain, R., & Raj, A. (2021). Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro. Cell Systems, 0(0). https://doi.org/10.1016/j.cels.2021.07.003 Cite
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