Mutations in the Transcription Factor FOXO1 Mimic Positive Selection Signals to Promote Germinal Center B Cell Expansion and Lymphomagenesis

By
Justin.choi
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Researchers investigated how forkhead box O1 (FOXO1) mutations targeting a regulatory axis in germinal center-derived B cell non-Hodgkin lymphomas contributed to lymphomagenesis.
[Immunity]
Roberto, M. P., Varano, G., Vinas-Castells, R., Holmes, A. B., Kumar, R., Pasqualucci, L., Farinha, P., Scott, D. W., & Dominguez-Sola, D. (2021). Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis. Immunity, 54(8), 1807-1824.e14. https://doi.org/10.1016/j.immuni.2021.07.009 Cite
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