Single-Cell Analysis Reveals Divergent Responses of Human Dendritic Cells to the MVA Vaccine

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The authors examined how these diverse responses are orchestrated in human dendritic cells (DCs). Single-cell analyses revealed that the response to modified vaccinia virus Ankara infection in DCs was limited to early viral gene expression.
[Science Signaling]
Döring, M., Azevedo, K. D., Blanco-Rodriguez, G., Nadalin, F., Satoh, T., Gentili, M., Lahaye, X., Silva, N. S. D., Conrad, C., Jouve, M., Centlivre, M., Lévy, Y., & Manel, N. (2021). Single-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine. Science Signaling, 14(697). https://doi.org/10.1126/scisignal.abd9720 Cite
Abstract