Restoring Mammary Gland Structures and Functions with Autogenous Cell Therapy

In vitro chemical induction with RepSox generated chemically induced mammary epithelial cells (CiMECs) with milk secreting functions from goat ear fibroblasts (GEFs). Single-cell RNA sequencing revealed that during the reprogramming process, GEFs may have sequentially undergone embryonic ectoderm-like and different MEC developmental states.