Regulation of Low-Density Lipoprotein Receptor Expression in Triple Negative Breast Cancer by EGFR-MAPK Signaling

Investigators identified how circulating low-density lipoprotein (LDL) cholesterol and tumor LDL receptor (LDLR) may have accelerated oncogenic processes by determining whether increased LDLR expression and cholesterol uptake were associated with the activation of the epidermal growth factor receptor (EGFR) signaling pathway in TNBC cell lines.