MAP4K4 Promotes Pancreatic Tumorigenesis via Phosphorylation and Activation of Mixed Lineage Kinase 3

Researchers identified MLK3 as a direct downstream target of MAP4K4. The MAP4K4 and MLK3 associated with each other, and MAP4K4 phosphorylates MLK3 on Thr738 and increased MLK3 kinase activity and downstream signaling.