Sanguisorbae Radix extract (SRE) effectively inhibited the PD-1/PD-L1 interaction, thereby improving T cell receptor signaling and the NFAT-mediated luciferase activity of T cells. SRE treatment reduced tumor growth in the humanized PD-L1 MC38 cell allograft humanized PD-1 mouse model.
[Frontiers in Immunology]