PLCγ2 Regulates TREM2 Signaling and Integrin-Mediated Adhesion and Migration of Human iPSC-Derived Macrophages

To explore the relationship between PLCγ2 and TREM2 and the role of PLCγ2 in regulating immune cell function, the authors generated human iPSC- derived macrophages from isogenic lines with homozygous PLCG2 knockout.