Adoptive Cell Therapy with Tumor-Specific Th9 Cells Induces Viral Mimicry to Eliminate Antigen-Loss-Variant Tumor Cells

Researchers demonstrated that murine and human T helper (Th) 9 cells, but not Th1/Tc1 or Th17 cells, expressing tumor-specific T cell receptors or CARs, eradicated advanced tumors that contained antigen-loss-variant.