IRF7 and RNH1 Are Modifying Factors of HIV-1 Reservoirs: A Genome-Wide Association Analysis

Scientists conducted a genome-wide quantitative trait locus analysis to probe functionally relevant genetic variants linked to levels of cell-associated HIV-1 DNA, CA HIV-1 RNA, and RNA:DNA ratio in CD4+ T cells isolated from blood from a cohort of 207 people living with HIV-1 on long-term suppressive antiretroviral treatment