CCR5 Antagonist Reduces HIV-Induced Amyloidogenesis, Tau Pathology, Neurodegeneration, and Blood-Brain Barrier Alterations in HIV-Infected Hu-PBL-NSG Mice

Investigators determined whether HIV-1 infection caused Alzheimer’s Disease-like pathologies in an HIV/AIDS humanized mouse model, and whether the CCR5 antagonist maraviroc altered HIV-induced pathologies.