CD8⁺ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4⁺ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis

Through the engineering of an HLA-DR1 chimeric Ag receptor (CAR), the authors produced CD8+ CAR T cells that target CD4+ T cells in an Ag-specific manner and tested their ability to inhibit the development of autoimmune arthritis in a mouse model.