Cytosporone B (Csn-B), an NR4A1 Agonist, Attenuates Acute Cardiac Allograft Rejection by Inducing Differential Apoptosis of CD4⁺ T Cells

Researchers revealed that nuclear receptor subfamily 4 Group A member 1 was upregulated during cardiac allograft rejection and that the increased Nr4A1 was primarily localized in intragraft-infiltrating CD4+ T cells.