A Novel STING Agonist-Adjuvanted Pan-Sarbecovirus Vaccine Elicits Potent and Durable Neutralizing Antibody and T Cell Responses in Mice, Rabbits and NHPs

Researchers discovered a new STING agonist, CF501, and found that CF501-adjuvanted RBD-Fc vaccine elicited significantly stronger neutralizing antibody and T cell responses than Alum- and cGAMP-adjuvanted RBD-Fc in mice.