Hemagglutinin-Based DNA Vaccines Containing Trimeric Self-Assembling Nanoparticles Confer Protection against Influenza

Aiming to develop an effective vaccine with rapid production, robust immunogenicity, and high protective efficiency, a DNA vaccine was designed by fusing influenza virus hemagglutinin (HA) with self-assembled ferritin nanoparticles, denoted as HA-F.