Skeletal Muscle-Specific Overexpression of miR-486 Limits Mammary Tumor-Induced Skeletal Muscle Functional Limitations

To determine whether skeletal muscle miR-486 was functionally similar in dystrophies and cancer, the authors performed functional limitations and biochemical studies of skeletal muscles of MMTV-Neu mice that mimicked HER2+ breast cancer and MMTV-PyMT mice that mimicked luminal subtype B breast cancer.