A Novel HIF-2α Targeted Inhibitor Suppresses Hypoxia-Induced Breast Cancer Stemness via SOD2-mtROS-PDI/GPR78-UPR^ER Axis

The authors illustrated that HIF-2α, but not HIF-1α, induced stemness in breast cancer cells under hypoxia through SOD2-mtROS-PDI/GRP78-UPRER pathway, linking mitochondrial metabolic state to endoplasmic reticulum response via mitochondrial reactive oxygen species level.