5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2

By
Justin.choi
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0
166
A natural product 5α-epoxyalantolactone (5α-EAL) was discovered as an anti-breast cancer stem cells lead compound 5α-EAL was found to be able to notably suppress the function of ANXA2 by covalently targeting cysteine 9 of ANXA2.
[Journal of Medicinal Chemistry]

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AbstractGraphical Abstract