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Pulmonary Cell NewsA natural product 5α-epoxyalantolactone (5α-EAL) was discovered as an anti-breast cancer stem cells lead compound 5α-EAL was found to be able to notably suppress the function of ANXA2 by covalently targeting cysteine 9 of ANXA2.
[Journal of Medicinal Chemistry]
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Wei, M., Zhou, Y., Li, C., Yang, Y., Liu, T., Liu, Y., Wei, Y., Liu, N., Liu, S., Wang, Q., Cao, S., Sun, Y., Sheng, P., Lu, C., Yang, C., Liu, X., & Yang, G. (2021). 5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.1c00267 Cite
