Laurisa Dohm

[Cell Reports] Using a combination of expression analysis, time-lapse imaging, and lineage-tracing approaches, investigators demonstrated that myeloid cells emerged from the endocardium in zebrafish embryos.

[Lancet Haematology] Patients aged 65 years or older with newly diagnosed, untreated primary diffuse large B-cell CNS lymphoma were enrolled if they had an Eastern Cooperative Oncology Group performance status of 0–2 and were fit for high-dose chemotherapy and autologous HSCT.

[ACS Nano] The 3D digital rolling circle amplification technique presented could distinguish BCR-ABL1 fusion transcript positive B-cell acute lymphoblastic leukemia cells with or without CD19 protein expression.

[Cell Reports] Scientists characterized the hepatic immune compartment of a neonatal peroxisome biogenesis disorders mouse model at single-cell resolution to establish the importance and function of peroxisomes in developmental hematopoiesis.

[Haematologica] By using a conditional knockout mouse model in which Ppm1b was specifically depleted in hematopoietic cells, researchers demonstrated that loss of Ppm1b impaired the HSC homeostasis and hematopoietic reconstitution.

[Science Translational Medicine] Investigators developed gene editing strategies targeting a corrective sequence into the human RAG1 gene by homology-directed repair and validated them by tailored 2D, 3D, and in vivo xenotransplant platforms to assess rescue of expression and function.