Researchers indicated that a high level of glucose exposure does not effect the invasion and migration of PANC-1 cells, while aspartame increases both of these aggressiveness criterias.
[Food and Chemical Toxicology]
7753456 R5GNR9MJ items 1 apa 0 default asc 1 162356 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/ %7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-273aec5bbfa23e5bddb6ddd06d5f8ebd%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22R5GNR9MJ%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22parsedDate%22%3A%222021-05-14%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EAspartame%20induces%20cancer%20stem%20cell%20enrichment%20through%20p21%2C%20NICD%20and%20GLI1%20in%20human%20PANC-1%20pancreas%20adenocarcinoma%20cells.%20%282021%29.%20%3Ci%3EFood%20and%20Chemical%20Toxicology%3C%5C%2Fi%3E%2C%20112264.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.fct.2021.112264%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.fct.2021.112264%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DR5GNR9MJ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Aspartame%20induces%20cancer%20stem%20cell%20enrichment%20through%20p21%2C%20NICD%20and%20GLI1%20in%20human%20PANC-1%20pancreas%20adenocarcinoma%20cells%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22This%20study%20aimed%20to%20investigate%20the%20molecular%20effects%20of%20the%20common%20natural%20sugar%20glucose%20and%20artificial%20sweetener%20aspartame%20on%20cancer%20stem%20cell%20%28CSC%29%5Cu2026%22%2C%22date%22%3A%222021%5C%2F05%5C%2F14%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.fct.2021.112264%22%2C%22ISSN%22%3A%220278-6915%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fabs%5C%2Fpii%5C%2FS0278691521002970%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%223XSKJF5U%22%5D%2C%22dateModified%22%3A%222021-05-18T19%3A13%3A49Z%22%7D%7D%5D%7DAspartame induces cancer stem cell enrichment through p21, NICD and GLI1 in human PANC-1 pancreas adenocarcinoma cells. (2021).
Food and Chemical Toxicology, 112264.
https://doi.org/10.1016/j.fct.2021.112264 Cite 
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