Transcriptome Analysis Using Patient iPSC-Derived Skeletal Myocytes: Bet1L as a New Molecule Possibly Linked to Neuromuscular Degeneration in ALS

To study common disease mechanisms in amyotrophic lateral sclerosis (ALS) skeletal muscle, the authors performed RNA sequencing of skeletal myocytes differentiated from induced pluripotent stem cells derived from familial ALS and sporadic ALS patients.