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Pulmonary Cell NewsSARS-CoV-2-infected cells showed accumulation of key metabolites, activation of autophagy inhibitors and reduction of proteins responsible for autophagy initiation, membrane nucleation, and phagophore formation, as well as autophagosome-lysosome fusion.
[Nature Communications]
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Gassen, N. C., Papies, J., Bajaj, T., Emanuel, J., Dethloff, F., Chua, R. L., Trimpert, J., Heinemann, N., Niemeyer, C., Weege, F., Hönzke, K., Aschman, T., Heinz, D. E., Weckmann, K., Ebert, T., Zellner, A., Lennarz, M., Wyler, E., Schroeder, S., … Müller, M. A. (2021). SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals. Nature Communications, 12(1), 3818. https://doi.org/10.1038/s41467-021-24007-w Cite
