Scientists report that CREPT, a recently identified tumor-promoting protein, was required for the maintenance of murine intestinal stem cells. CREPT was preferably expressed in the crypts but not in the villi.
[Nature Communications]
6445218 {6445218:I9L3PTQJ} apa 50 1 157791 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-faa86692ad1be8aea3e527c41d7792ea%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22I9L3PTQJ%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Yang%20et%20al.%22%2C%22parsedDate%22%3A%222021-01-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EYang%2C%20L.%2C%20Yang%2C%20H.%2C%20Chu%2C%20Y.%2C%20Song%2C%20Y.%2C%20Ding%2C%20L.%2C%20Zhu%2C%20B.%2C%20Zhai%2C%20W.%2C%20Wang%2C%20X.%2C%20Kuang%2C%20Y.%2C%20Ren%2C%20F.%2C%20Jia%2C%20B.%2C%20Wu%2C%20W.%2C%20Ye%2C%20X.%2C%20Wang%2C%20Y.%2C%20%26amp%3B%20Chang%2C%20Z.%20%282021%29.%20CREPT%20is%20required%20for%20murine%20stem%20cell%20maintenance%20during%20intestinal%20regeneration.%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%281%29%2C%20270.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-020-20636-9%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-020-20636-9%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DI9L3PTQJ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22CREPT%20is%20required%20for%20murine%20stem%20cell%20maintenance%20during%20intestinal%20regeneration%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liu%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haiyan%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yunxiang%22%2C%22lastName%22%3A%22Chu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yunhao%22%2C%22lastName%22%3A%22Song%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lidan%22%2C%22lastName%22%3A%22Ding%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bingtao%22%2C%22lastName%22%3A%22Zhu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wanli%22%2C%22lastName%22%3A%22Zhai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xuning%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanshen%22%2C%22lastName%22%3A%22Kuang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fangli%22%2C%22lastName%22%3A%22Ren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baoqing%22%2C%22lastName%22%3A%22Jia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wei%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiongjun%22%2C%22lastName%22%3A%22Ye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yinyin%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhijie%22%2C%22lastName%22%3A%22Chang%22%7D%5D%2C%22abstractNote%22%3A%22Intestinal%20stem%20cells%20%28ISCs%29%20residing%20in%20the%20crypts%20are%20critical%20for%20the%20continual%20self-renewal%20and%20rapid%20recovery%20of%20the%20intestinal%20epithelium.%20The%20regulatory%20mechanism%20of%20ISCs%20is%20not%20fully%20understood.%20Here%20we%20report%20that%20CREPT%2C%20a%20recently%20identified%20tumor-promoting%20protein%2C%20is%20required%20for%20the%20maintenance%20of%20murine%20ISCs.%20CREPT%20is%20preferably%20expressed%20in%20the%20crypts%20but%20not%20in%20the%20villi.%20Deletion%20of%20CREPT%20in%20the%20intestinal%20epithelium%20of%20mice%20%28Vil-CREPTKO%29%20results%20in%20lower%20body%20weight%20and%20slow%20migration%20of%20epithelial%20cells%20in%20the%20intestine.%20Vil-CREPTKO%20intestine%20fails%20to%20regenerate%20after%20X-ray%20irradiation%20and%5Cu00a0dextran%20sulfate%20sodium%20%28DSS%29%20treatment.%20Accordingly%2C%20the%20deletion%20of%20CREPT%20decreases%20the%20expression%20of%20genes%20related%20to%20the%20proliferation%20and%20differentiation%20of%20ISCs%20and%20reduces%20Lgr5%2B%20cell%20numbers%20at%20homeostasis.%20We%20identify%20that%20CREPT%20deficiency%20downregulates%20Wnt%20signaling%20by%20impairing%20%5Cu03b2-catenin%20accumulation%20in%20the%20nucleus%20of%20the%20crypt%20cells%20during%20regeneration.%20Our%20study%20provides%20a%20previously%20undefined%20regulator%20of%20ISCs.%22%2C%22date%22%3A%222021-01-11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-020-20636-9%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-020-20636-9%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-01-11T20%3A09%3A46Z%22%7D%7D%5D%7D
Yang, L., Yang, H., Chu, Y., Song, Y., Ding, L., Zhu, B., Zhai, W., Wang, X., Kuang, Y., Ren, F., Jia, B., Wu, W., Ye, X., Wang, Y., & Chang, Z. (2021). CREPT is required for murine stem cell maintenance during intestinal regeneration. Nature Communications, 12(1), 270. https://doi.org/10.1038/s41467-020-20636-9 Cite