Investigators demonstrated the use of human small intestinal organoids to model ischemia-reperfusion injury by exposing organoids to hypoxia and reoxygenation.
[Cell Death & Disease]
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Kip, A. M., Soons, Z., Mohren, R., Duivenvoorden, A. A. M., Röth, A. A. J., Cillero-Pastor, B., Neumann, U. P., Dejong, C. H. C., Heeren, R. M. A., Olde Damink, S. W. M., & Lenaerts, K. (2021). Proteomics analysis of human intestinal organoids during hypoxia and reoxygenation as a model to study ischemia-reperfusion injury. Cell Death & Disease, 12(1), 1–13. https://doi.org/10.1038/s41419-020-03379-9 Cite