Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsResearchers analyzed human umbilical-cord-derived MSCs from 32 donors and revealed donor-dependent variations in two non-correlated properties; cell proliferation, and immune modulatory functions in vitro and in vivo, which might explain inconsistent clinical efficacies of MSCs.
[Cell Death & Disease]
6445212 JKLJZ3Z6 items 1 apa 0 default asc 1 160925 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-4b95eb2ab6c405cf5f6c7697c035f653%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22JKLJZ3Z6%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhang%2C%20C.%2C%20Zhou%2C%20L.%2C%20Wang%2C%20Z.%2C%20Gao%2C%20W.%2C%20Chen%2C%20W.%2C%20Zhang%2C%20H.%2C%20Jing%2C%20B.%2C%20Zhu%2C%20X.%2C%20Chen%2C%20L.%2C%20Zheng%2C%20C.%2C%20Shi%2C%20K.%2C%20Wu%2C%20L.%2C%20Cheng%2C%20L.%2C%20Zhang%2C%20K.%2C%20%26amp%3B%20Sun%2C%20Y.%20E.%20%282021%29.%20Eradication%20of%20specific%20donor-dependent%20variations%20of%20mesenchymal%20stem%20cells%20in%20immunomodulation%20to%20enhance%20therapeutic%20values.%20%3Ci%3ECell%20Death%20%26amp%3B%20Disease%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%284%29%2C%201%26%23x2013%3B11.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03644-5%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03644-5%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DJKLJZ3Z6%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Eradication%20of%20specific%20donor-dependent%20variations%20of%20mesenchymal%20stem%20cells%20in%20immunomodulation%20to%20enhance%20therapeutic%20values%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chunxue%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liqiang%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhen%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wenxia%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wei%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huina%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bo%22%2C%22lastName%22%3A%22Jing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xu%22%2C%22lastName%22%3A%22Zhu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lei%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Changhong%22%2C%22lastName%22%3A%22Zheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaiyan%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Li%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liming%22%2C%22lastName%22%3A%22Cheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kunshan%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi%20Eve%22%2C%22lastName%22%3A%22Sun%22%7D%5D%2C%22abstractNote%22%3A%22Mesenchymal%20stem%20cells%20%28MSCs%29%20are%20one%20of%20the%20most%20widely%20clinically%20trialed%20stem%20cells%2C%20due%20to%20their%20abilities%20to%20differentiate%20into%20multiple%20cell%20lineages%2C%20to%20secrete%20regenerative%5C%2Frejuvenative%20factors%2C%20and%20to%20modulate%20immune%20functions%2C%20among%20others.%20In%20this%20study%2C%20we%20analyzed%20human%20umbilical-cord-derived%20MSCs%20from%2032%20donors%20and%20revealed%20donor-dependent%20variations%20in%20two%20non-correlated%20properties%2C%20%281%29%20cell%20proliferation%2C%20and%20%282%29%20immune%20modulatory%20functions%20in%20vitro%20and%20in%20vivo%2C%20which%20might%20explain%20inconsistent%20clinical%20efficacies%20of%20MSCs.%20Through%20unbiased%20transcriptomic%20analyses%2C%20we%20discovered%20that%20IFN-%5Cu03b3%20and%20NF-%5Cu03baB%20signaling%20were%20positively%20associated%20with%20immune%20modulatory%20function%20of%20MSCs.%20Activation%20of%20these%20two%20pathways%20via%20IFN-%5Cu03b3%20and%20TNF-%5Cu03b1%20treatment%20eradicated%20donor-dependent%20variations.%20Additional%20transcriptomic%20analyses%20revealed%20that%20treatment%20with%20these%20two%20factors%2C%20while%20having%20abolished%20donor-dependent%20variations%20in%20immune%20modulatory%20function%2C%20did%20not%20overall%20make%20different%20donor-derived%20MSCs%20the%20same%20at%20whole%20transcriptomic%20levels%2C%20demonstrating%20that%20the%20cells%20were%20still%20different%20in%20many%20other%20biological%20perspectives%2C%20and%20may%20not%20perform%20equally%20for%20therapeutic%20purposes%20other%20than%20immune%20modulation.%20Pre-selection%20or%20pre-treatment%20to%20eradicate%20MSC%20variations%20in%20a%20disease-treatment-specific%20manner%20would%20therefore%20be%20necessary%20to%20ensure%20clinical%20efficacies.%20Together%20this%20study%20provided%20novel%20insights%20into%20the%20quality%20control%20perspective%20of%20using%20different-donor-derived%20MSCs%20to%20treat%20inflammation-related%20clinical%20conditions%20and%5C%2For%20autoimmune%20diseases.%22%2C%22date%22%3A%222021-04-06%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41419-021-03644-5%22%2C%22ISSN%22%3A%222041-4889%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41419-021-03644-5%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-07T18%3A11%3A26Z%22%7D%7D%5D%7D
Zhang, C., Zhou, L., Wang, Z., Gao, W., Chen, W., Zhang, H., Jing, B., Zhu, X., Chen, L., Zheng, C., Shi, K., Wu, L., Cheng, L., Zhang, K., & Sun, Y. E. (2021). Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values. Cell Death & Disease, 12(4), 1–11. https://doi.org/10.1038/s41419-021-03644-5 Cite
